Comfort & I-55 Hotel 4*
Comfort & I-55
Hotel Comfort & I-55 Sikeston
Comfort & I-55
Comfort & I-55
Hotel Comfort & I-55 4*
Comfort & I-55 Sikeston
Comfort & I-55 Sikeston
Comfort & I-55
Comfort & I-55 Hotel
Comfort & I-55 Hotel Sikeston
Comfort & I-55 Hotel
Comfort & I-55 Sikeston
Comfort & I-55
Comfort & I-55 Hotel
Comfort & I-55 Hotel Sikeston
Comfort & I-55
Comfort & I-55 Hotel
Hotel Comfort & I-55 Sikeston
Comfort & I-55 4* Sikeston
Comfort & I-55 Hotel Sikeston
Comfort & I-55 4* Sikeston
Comfort & I-55 Hotel 4*
Hotel Comfort & I-55 4*
Comfort & I-55 Hotel 4*
Comfort & I-55 Hotel Sikeston
Hotel Comfort & I-55
Comfort & I-55 4*
Comfort & I-55 Hotel
Comfort & I-55 4*
Hotel Comfort & I-55
Hotel Comfort & I-55 Sikeston
Comfort & I-55 Hotel 4*
Hotel Comfort & I-55 4*
Comfort & I-55
Comfort & I-55 Sikeston
Comfort & I-55 Hotel 4*
Hotel Comfort & I-55
Comfort & I-55 Hotel 4*
Comfort & I-55 Hotel Sikeston
Comfort & I-55 4* Sikeston
Hotel Comfort & I-55 Sikeston
Comfort & I-55 4*
Comfort & I-55 4*
Comfort & I-55 4*
Hotel Comfort & I-55 Sikeston
Comfort & I-55 Hotel
Comfort & I-55
Comfort & I-55 Hotel 4*
Hotel Comfort & I-55
Hotel Comfort & I-55
Comfort & I-55 Sikeston
Comfort & I-55 Hotel
Comfort & I-55 Hotel 4*
Hotel Comfort & I-55 Sikeston
Hotel Comfort & I-55
Comfort & I-55 Sikeston
Comfort & I-55 Hotel
Comfort & I-55 4*
Comfort & I-55 Hotel Sikeston
Comfort & I-55
Comfort & I-55 Hotel
Hotel Comfort & I-55 4*
Hotel Comfort & I-55 Sikeston
Comfort & I-55 4* Sikeston
Hotel Comfort & I-55
Hotel Comfort & I-55 4*
Hotel Comfort & I-55 4*
Comfort & I-55 Hotel Sikeston
Hotel Comfort & I-55 4*
Hotel Comfort & I-55 Sikeston
Comfort & I-55
Hotel Comfort & I-55
Comfort & I-55 4* Sikeston
Comfort & I-55 4* Sikeston
Comfort & I-55 Hotel Sikeston
Hotel Comfort & I-55 4*
Comfort & I-55 Hotel 4*
Comfort & I-55 Hotel Sikeston
Comfort & I-55 Hotel 4*
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Comfort Inn & Suites Sikeston I-55

Sikeston, United States View on map
7.9 Good Based on 210 reviews
Editor's Pick

"Year-round, guests swim in an indoor pool and hot tub. The breakfast includes a wide spread of choices. Best for road-trippers, less so for anyone needing quick, front-door parking."

Cody Merrick
Travel & Culture Writer · May 2026
From US$ 125 US$ 108 per night
Save 13%
Check-in
24 Sept 2026
Check-out
25 Sept 2026
Guests
2 guests

Adults:

2

Children:

0
  • Free cancellation
    on many rooms
  • No booking fees
    Pay at the hotel
  • Secure booking
    Your data is safe
  • Best price guarantee
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Why guests choose Comfort Inn & Suites Sikeston I-55

  • Heated Pool
    Indoor hot tub
  • Free Breakfast
    Biscuits & gravy
  • Pet Friendly
    Small pet fee
  • Free Parking
    Large vehicle spots
  • Bootheel Golf
    Championship course
  • Business Center
    Copy & fax
Comfort Inn & Suites Sikeston I-55 1 / 80

Overview

Situated 2.1 miles from Malco Sikeston Cinema and Grill in Sikeston, the heritage Comfort Inn & Suites Sikeston I-55 offers a private art gallery. This comfortable hotel features Wi-Fi in public areas and free private parking on site.

The hotel is a great place to stay due to its convenient location in Sikeston. Sikeston Depot Museum & Gallery is about 15 minutes' drive from the Comfort Inn & Suites Sikeston I-55, while Cadiz is 95 miles away. The accommodation is also within reach of the Mississippi River.

Providing a separate toilet, some bathrooms are also equipped with a hairdryer.

A day at the Sikeston hotel begins with a free breakfast. Burger King is only steps away from this 4-star property.

  • Check-in
    from 14:00 until 23:59
  • Check-out
    until 11:00
  • Hotel class
    4 stars
Comfort Inn & Suites Sikeston I-55
Our tips

Should you book Comfort Inn & Suites Sikeston I-55?

By Talia Rosen, Senior Travel Writer.

Perfect if you
  • Travel with pets - this Sikeston hotel welcomes pets with no deposit or fee mentioned.
  • Need an indoor pool and hot tub open year-round for swimming and relaxing.
  • Want a complimentary American breakfast served daily with biscuits and gravy.
Maybe skip if you
  • Expect dining beyond fast food - only McDonald's and Burger King are within walking distance.
  • Need a gym with extensive equipment - the fitness room is small with only a newer machine.
Best for
  • An indoor pool and hot tub available year-round
  • Complimentary American breakfast with hearty options like biscuits and gravy

Facilities of Comfort Inn & Suites Sikeston I-55

General
  • Wi-Fi
  • Parking
  • Safe deposit box
  • Pets allowed
Leisure & Sports
  • Indoor swimming pool
Room Amenities
  • Washing machine
  • AM/FM alarm clock
  • Cots

Policies

Comfort Inn & Suites Sikeston I-55 applies these conditions to all bookings.
Check-in / Check-out
Check-in
from 14:00 until 23:59
Check-out
until 11:00
Important info
  • Children and extra beds
  • There are no cribs provided in a room.

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Check-in
24 Sept 2026
Check-out
25 Sept 2026
Guests
2 guests

Adults:

2

Children:

0
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